Summary | Mutation origin | Mutation description | Expression | Phenotypes | Disease models | Find Mice (IMSR) | References

Symbol: Crxtm1Clc Name: cone-rod homeobox; targeted mutation 1, Constance L Cepko MGI ID: MGI:2181191 Synonyms: Crx- Gene: Crx  Location: Chr7:15599872-15613880 bp, - strand  Genetic Position: Chr7, 8.6 cM Alliance: Crxtm1Clc page

Outer retina microscopy of Crxtm1Clc/Crxtm1Clc mice Show the 10 phenotype image(s) involving this allele.

Germline Transmission:	Earliest citation of germline transmission: J:58796
Parent Cell Line:	TC1/TC-1 (ES Cell)
Strain of Origin:	129S6/SvEvTac

Allele Type:    Targeted (Null/knockout) Mutations:    Insertion, Intragenic deletion   Mutation details: The homeodomain coding region containing exon 3 and a portion of exon 4 was replaced by a neomycin selection cassette. RT-PCR analysis showed an absence of transcript in the retinas of homozygous mutant mice. (J:58796)

View phenotypes and curated references for all genotypes (concatenated display).

In Mice Carrying this Mutation:	12 assay results 6 RNA-Seq or microarray experiment(s)
In Structures Affected by this Mutation:	5 anatomical structure(s)

Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:	Mouse Strains: 2 strains available      Cell Lines: 0 lines available
Carrying any Crx Mutation:	26 strains or lines available

Original:	J:58796 Furukawa T, et al., Retinopathy and attenuated circadian entrainment in Crx-deficient mice. Nat Genet. 1999 Dec;23(4):466-70
All:	32 reference(s)