Summary | Mutation origin | Mutation description | Expression | Phenotypes | Find Mice (IMSR) | References

Symbol:	Nhlh1tm1Thbr
Name:	nescient helix loop helix 1; targeted mutation 1, Thomas Braun
MGI ID:	MGI:2180862
Synonyms:	NSCL-1-
Gene:	Nhlh1  Location: Chr1:171879859-171885140 bp, - strand  Genetic Position: Chr1, 79.54 cM
Alliance:	Nhlh1tm1Thbr page

Germline Transmission:	Earliest citation of germline transmission: J:73967
Parent Cell Line:	J1 (ES Cell)
Strain of Origin:	129S4/SvJae

Allele Type:    Targeted (Null/knockout, Reporter) Mutations:    Insertion, Intragenic deletion   Mutation details: An IRES-lacZ-neomycin resistance cassette replaced the most of the second exon including almost the entire DNA binding bHLH region and most of the coding region, and placed lacZ under control of endogenous transcriptional elements. RT-PCR analysis of brain did not detect transcript in homozygous mutant E18.5 embryos. Beta-galactosidase was expresssed under the control of the endogenous promoter. (J:73967)

View phenotypes and curated references for all genotypes (concatenated display).

In Mice Carrying this Mutation:

101 assay results

Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:	Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Nhlh1 Mutation:	15 strains or lines available

Original:	J:73967 Kruger M, et al., The neuronal basic helix-loop-helix transcription factor NSCL-1 is dispensable for normal neuronal development. Mol Cell Biol. 2002 Feb;22(3):792-800
All:	3 reference(s)