Pik3cbtm1Nbm
Targeted Allele Detail
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| Symbol: |
Pik3cbtm1Nbm |
| Name: |
phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit beta; targeted mutation 1, Robert L Nussbaum |
| MGI ID: |
MGI:2180703 |
| Synonyms: |
p110beta-, Pik3cbdel |
| Gene: |
Pik3cb Location: Chr9:98920455-99022264 bp, - strand Genetic Position: Chr9, 51.41 cM, cytoband E4
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| Alliance: |
Pik3cbtm1Nbm page
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Phase contrast microscopy of blastobysts flushed at day 3.5 d.p.c.
Show the 1 phenotype image(s) involving this allele.
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| Germline Transmission: |
Earliest citation of germline transmission:
J:75617
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| Parent Cell Line: |
TC1/TC-1 (ES Cell)
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| Strain of Origin: |
129S6/SvEvTac
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| Allele Type: |
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Targeted (Null/knockout) |
| Mutations: |
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Insertion, Intragenic deletion
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Mutation details: Two exons spanning nucleotides 2943-3180 were replaced with a PGK-neo cassette via homologous recombination. The gene targeting event deletes 79 amino acids from position 982-1060 forming 28% of the phosphoinositol 3-kinase catalytic domain.
(J:75617)
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View phenotypes and curated references for all genotypes (concatenated display).
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| Mouse strains and cell lines
available from the International Mouse Strain Resource
(IMSR) |
| Carrying this Mutation: |
Mouse Strains: 0 strains available
Cell Lines: 0 lines available
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| Carrying any Pik3cb Mutation: |
151 strains or lines available
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| Original: |
J:75617 Bi L, et al., Early embryonic lethality in mice deficient in the p110beta catalytic subunit of PI 3-kinase. Mamm Genome. 2002 Mar;13(3):169-72 |
| All: |
4 reference(s) |
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Analysis Tools
