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Cd247tm1Mal
Targeted Allele Detail
Summary
Symbol: Cd247tm1Mal
Name: CD247 antigen; targeted mutation 1, Bernard Malissen
MGI ID: MGI:2180466
Synonyms: zeta-sd
Gene: Cd247  Location: Chr1:165616250-165704846 bp, + strand  Genetic Position: Chr1, 73.14 cM, cytoband G-H
Alliance: Cd247tm1Mal page
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:15272
Parent Cell Line:  Bruce 4 (ES Cell)
Strain of Origin:  B6.Cg-Thy1a
Mutation
description
Allele Type:    Targeted (Null/knockout)
Mutation:    Insertion
 
Mutation detailsThe gene was disrupted by insertion of a neomycin resistance cassette into exon 2 via homologous recombination. Absence of gene expression in thymocytes of homozygous mutant animals was verified by Western blot analysis. This mutation disrupts the two major isoforms of this locus. (J:15272)
Phenotypes
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View phenotypes and curated references for all genotypes (concatenated display).
Expression
In Structures Affected by this Mutation: 1 anatomical structure(s)
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 1 strain available      Cell Lines: 0 lines available
Carrying any Cd247 Mutation:  11 strains or lines available
References
Original:  J:15272 Malissen M, et al., T cell development in mice lacking the CD3-zeta/eta gene. EMBO J. 1993 Nov;12(11):4347-55
All:  13 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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last database update
03/19/2024
MGI 6.23
The Jackson Laboratory