Summary | Mutation origin | Mutation description | Expression | Phenotypes | Find Mice (IMSR) | References

Symbol:	Npas2tm1Slm
Name:	neuronal PAS domain protein 2; targeted mutation 1, Steven L McKnight
MGI ID:	MGI:2180392
Synonyms:	Npas2-, NPAS2-lacZ, NPAS-deltabHLH
Gene:	Npas2  Location: Chr1:39233013-39402321 bp, + strand  Genetic Position: Chr1, 17.98 cM
Alliance:	Npas2tm1Slm page

Germline Transmission:	Earliest citation of germline transmission: J:63035
Parent Cell Line:	Not Specified (ES Cell)
Strain of Origin:	129S6/SvEvTac

Allele Type:    Targeted (Null/knockout, Reporter) Mutation:    Insertion   Mutation details: A lacZ-neo fusion gene was inserted into exon 2, which encodes the basic helix-loop-helix (bHLH) domain. Northern blot analysis using a bHLH probe failed to detect transcript in total RNA isolated from homozygous mutant brain tissue. A second transcript, in which the inserted lacZ-neo gene is excised, was observed. This transcript was also found to be functionally inactive due to the lack of the bHLH domain. (J:63035)

View phenotypes and curated references for all genotypes (concatenated display).

In Mice Carrying this Mutation:	1 RNA-Seq or microarray experiment(s)
In Structures Affected by this Mutation:	4 anatomical structure(s)

Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:	Mouse Strains: 1 strain available      Cell Lines: 0 lines available
Carrying any Npas2 Mutation:	45 strains or lines available

Original:	J:63035 Garcia JA, et al., Impaired cued and contextual memory in NPAS2-deficient mice. Science. 2000 Jun 23;288(5474):2226-30
All:	24 reference(s)