Summary | Mutation origin | Mutation description | Expression | Phenotypes | Find Mice (IMSR) | References

Symbol:	Stx4atm1Jpes
Name:	syntaxin 4A (placental); targeted mutation 1, Jeffrey E Pessin
MGI ID:	MGI:2180164
Synonyms:	Stx4atm1Jepn, syn4-, Syn4a-
Gene:	Stx4a  Location: Chr7:127439832-127450160 bp, + strand  Genetic Position: Chr7, 69.77 cM, cytoband F4
Alliance:	Stx4atm1Jpes page

Germline Transmission:	Earliest citation of germline transmission: J:69598
Parent Cell Line:	R1 (ES Cell)
Strain of Origin:	(129X1/SvJ x 129S1/Sv)F1-Kitl+

Allele Type:    Targeted (Null/knockout) Mutations:    Insertion, Intragenic deletion   Mutation details: 3.3 kb of the gene encompassing exons 1-5, and including the translation initiation site, was replaced with a neo resistance cassette via homologous recombination. Reduced protein expression was demonstrated by western blotting in heterozygous mice. (J:69598)

View phenotypes and curated references for all genotypes (concatenated display).

In Structures Affected by this Mutation:

1 anatomical structure(s)

Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:	Mouse Strains: 1 strain available      Cell Lines: 0 lines available
Carrying any Stx4a Mutation:	20 strains or lines available

Original:	J:69598 Yang C, et al., Syntaxin 4 heterozygous knockout mice develop muscle insulin resistance. J Clin Invest. 2001 May;107(10):1311-8
All:	4 reference(s)