Summary | Mutation origin | Mutation description | Phenotypes | Find Mice (IMSR) | References

Symbol:	Syt1tm4Sud
Name:	synaptotagmin I; targeted mutation 4, Thomas C Sudhof
MGI ID:	MGI:2180149
Synonyms:	K236Q
Gene:	Syt1  Location: Chr10:108333511-108846843 bp, - strand  Genetic Position: Chr10, 56.52 cM
Alliance:	Syt1tm4Sud page

Germline Transmission:	Earliest citation of germline transmission: J:76452
Parent Cell Line:	E14 (ES Cell)
Strain of Origin:	129P2/OlaHsd

Allele Type:    Targeted Mutations:    Insertion, Single point mutation   Mutation details: Insertion of a neomycin resistance cassette into intron 1 and a lysine to glutamine point mutation at position 236 of exon 1 (K236Q) was introduced via homologous recombination. Western blot of brain homogenates from homozygous mutant animals verified the presence of protein expression and enzyme assays demonstrated similar phospholipid- and syntaxin-binding ability and calcium affinity compared to wild-type. (J:76452)

View phenotypes and curated references for all genotypes (concatenated display).

Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:	Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Syt1 Mutation:	39 strains or lines available

Original:	J:76452 Fernandez-Chacon R, et al., Synaptotagmin I functions as a calcium regulator of release probability. Nature. 2001 Mar 1;410(6824):41-9
All:	2 reference(s)