Summary | Mutation origin | Mutation description | Expression | Phenotypes | Find Mice (IMSR) | Notes | References

Symbol:	Adh1tm2Gdu
Name:	alcohol dehydrogenase 1 (class I); targeted mutation 2, Gregg Duester
MGI ID:	MGI:2180099
Synonyms:	Adh1-
Gene:	Adh1  Location: Chr3:137983346-137996459 bp, + strand  Genetic Position: Chr3, 64.16 cM
Alliance:	Adh1tm2Gdu page

Germline Transmission:	Earliest citation of germline transmission: J:76055
Parent Cell Line:	R1 (ES Cell)
Strain of Origin:	(129X1/SvJ x 129S1/Sv)F1-Kitl+

Allele Type:    Targeted (Null/knockout) Mutation:    Intragenic deletion   Mutation details: Exons 7 through 9 and the polyadenylation signal were replaced with a PGK-hygro gene downstream of exon 6. This construct was developed by altering a previously described construct, tm1Due, containing a neomycin selection gene, for use in the generation of a double knockout. (J:76055)

View phenotypes and curated references for all genotypes (concatenated display).

In Structures Affected by this Mutation:

1 anatomical structure(s)

Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:	Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Adh1 Mutation:	32 strains or lines available

Original:	J:76055 Molotkov A, et al., Distinct Retinoid Metabolic Functions for Alcohol Dehydrogenase Genes Adh1 and Adh4 in Protection against Vitamin A Toxicity or Deficiency Revealed in Double Null Mutant Mice. J Biol Chem. 2002 Apr 19;277(16):13804-11
All:	3 reference(s)