Summary | Mutation origin | Mutation description | Expression | Phenotypes | Disease models | Find Mice (IMSR) | References

Symbol: Acadltm1Uab Name: acyl-Coenzyme A dehydrogenase, long-chain; targeted mutation 1, University of Alabama MGI ID: MGI:2180079 Synonyms: LCAD- Gene: Acadl  Location: Chr1:66869998-66902436 bp, - strand  Genetic Position: Chr1, 33.64 cM Alliance: Acadltm1Uab page

Histopathology on Acadltm1Uab/Acadl+ and Acadltm1Uab/Acadltm1Uab mice Show the 1 phenotype image(s) involving this allele.

Germline Transmission:	Earliest citation of germline transmission: J:51660
Parent Cell Line:	TC1/TC-1 (ES Cell)
Strain of Origin:	129S6/SvEvTac

Allele Type:    Targeted (Null/knockout) Mutation:    Insertion   Mutation details: A gap-repair insertion was used to duplicate exons 3 and 4. Analysis of the mutant cDNA showed a duplication of exons 3 and 4 as well as the excision of the neomycin selection gene and the plasmid sequence. Northern blot analysis demonstrated normal expression levels of mutant transcript. No protein was detected by immunoblots in isolates from liver mitochondria of homozygous mutant animals. (J:51660)

View phenotypes and curated references for all genotypes (concatenated display).

In Structures Affected by this Mutation:

4 anatomical structure(s)

Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:	Mouse Strains: 1 strain available      Cell Lines: 0 lines available
Carrying any Acadl Mutation:	22 strains or lines available

Original:	J:51660 Kurtz DM, et al., Targeted disruption of mouse long-chain acyl-CoA dehydrogenase gene reveals crucial roles for fatty acid oxidation. Proc Natl Acad Sci U S A. 1998 Dec 22;95(26):15592-7
All:	29 reference(s)