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Targeted Allele Detail
Symbol: Actc1tm1Jll
Name: actin, alpha, cardiac muscle 1; targeted mutation 1, James Lessard
MGI ID: MGI:2180072
Synonyms: cardiac alpha-actin-
Gene: Actc1  Location: Chr2:113877763-113883356 bp, - strand  Genetic Position: Chr2, 57.55 cM
Alliance: Actc1tm1Jll page
Myofibrillar disarray in newborn Actc1tm1Jll/Actc1tm1Jll hearts

Show the 2 phenotype image(s) involving this allele.

Germline Transmission:  Earliest citation of germline transmission: J:40165
Parent Cell Line:  E14TG2a (ES Cell)
Strain of Origin:  129P2/OlaHsd
Allele Type:    Targeted (Null/knockout)
Mutation:    Insertion
Mutation detailsA targeting construct containing HPRT was used to disrupt exon 2. A truncated transcript was detected in extracts from the hearts of homozygous mutant mice, but was shown to be non-coding by the lack of either a normal or truncated peptide in Western blots. (J:40165)
View phenotypes and curated references for all genotypes (concatenated display).
In Structures Affected by this Mutation: 5 anatomical structures
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Actc1 Mutation:  13 strains or lines available
Original:  J:40165 Kumar A, et al., Rescue of cardiac alpha-actin-deficient mice by enteric smooth muscle gamma-actin. Proc Natl Acad Sci U S A. 1997 Apr 29;94(9):4406-11
All:  3 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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MGI 6.22
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