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Npas3tm1Mesu
Targeted Allele Detail
Summary
Symbol: Npas3tm1Mesu
Name: neuronal PAS domain protein 3; targeted mutation 1, Mary E Sunday
MGI ID: MGI:3852356
Gene: Npas3  Location: Chr12:53294940-54118958 bp, + strand  Genetic Position: Chr12, 22.31 cM, cytoband C1
Alliance: Npas3tm1Mesu page
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:150793
Parent Cell Line:  iTL1 (ES Cell)
Strain of Origin:  129S6/SvEvTac
Mutation
description
Allele Type:    Targeted (Null/knockout)
Mutations:    Insertion, Intragenic deletion
 
Mutation detailsPart of exon 4 was replaced with a neo cassette. This deletion is predicted to produce a protein lacking part of the PAS-A domain and all of the PAS-B domain. The absence of transcript expression was confirmed by QRT-PCR on E12.5 lung extracts. (J:150793)
Phenotypes
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View phenotypes and curated references for all genotypes (concatenated display).
Expression
In Structures Affected by this Mutation: 8 anatomical structure(s)
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Npas3 Mutation:  41 strains or lines available
References
Original:  J:150793 Zhou S, et al., NPAS3 is a trachealess homolog critical for lung development and homeostasis. Proc Natl Acad Sci U S A. 2009 Jul 14;106(28):11691-6
All:  2 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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last database update
03/19/2024
MGI 6.23
The Jackson Laboratory