Summary | Mutation origin | Mutation description | Phenotypes | Find Mice (IMSR) | References

Symbol:	Hprt1tm1(Rcan1)Zyga
Name:	hypoxanthine phosphoribosyltransferase 1; targeted mutation 1, Zygmunt Galdzicki
MGI ID:	MGI:3850734
Gene:	Hprt1  Location: ChrX:52077014-52110536 bp, + strand  Genetic Position: ChrX, 29.31 cM, cytoband A6
Alliance:	Hprt1tm1(Rcan1)Zyga page

Germline Transmission:	Earliest citation of germline transmission: J:150286
Parent Cell Line:	BK4 (ES Cell)
Strain of Origin:	129P2/OlaHsd

Allele Type:    Targeted (Inserted expressed sequence) Mutations:    Insertion, Intragenic deletion   Hprt1tm1(Rcan1)Zyga expresses 1 gene Knock-in expresses: Organism Expressed Gene Note mouse Rcan1 (MGI:1890564)   Mutation details: The non-functional exon 1 was replaced with a myc-tagged Rcan1 cDNA, 2 kb of the native Rcan1 promoter, and a functional Hprt exon 1. (J:150286)

View phenotypes and curated references for all genotypes (concatenated display).

Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:	Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Hprt1 Mutation:	1273 strains or lines available

Original:	J:150286 Baek KH, et al., Down's syndrome suppression of tumour growth and the role of the calcineurin inhibitor DSCR1. Nature. 2009 Jun 25;459(7250):1126-30
All:	6 reference(s)