Summary | Mutation origin | Mutation description | Phenotypes | Find Mice (IMSR) | References

Symbol:	Kdrtm2Sato
Name:	kinase insert domain protein receptor; targeted mutation 2, Thomas N Sato
MGI ID:	MGI:3850417
Synonyms:	Kdrfl, VEGFR2e3loxP, VEGFR2loxP
Gene:	Kdr  Location: Chr5:76093487-76139118 bp, - strand  Genetic Position: Chr5, 40.23 cM
Alliance:	Kdrtm2Sato page

Germline Transmission:	Earliest citation of germline transmission: J:149917
Parent Cell Line:	CJ7 (ES Cell)
Strain of Origin:	129S1/Sv-Oca2+ Tyr+ Kitl+

Allele Type:    Targeted (Conditional ready, No functional change) Mutation:    Insertion   Mutation details: A loxP site was inserted upstream of exon 3 and an frt flanked pgk-neo cassette followed by a loxP site were inserted downstream of exon 3 via homologous recombination. (J:149917)

View phenotypes and curated references for all genotypes (concatenated display).

Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:	Mouse Strains: 1 strain available      Cell Lines: 0 lines available
Carrying any Kdr Mutation:	71 strains or lines available

Original:	J:149917 Hooper AT, et al., Engraftment and reconstitution of hematopoiesis is dependent on VEGFR2-mediated regeneration of sinusoidal endothelial cells. Cell Stem Cell. 2009 Mar 6;4(3):263-74
All:	35 reference(s)