Efnb1tm4Sor
Targeted Allele Detail
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| Symbol: |
Efnb1tm4Sor |
| Name: |
ephrin B1; targeted mutation 4, Philippe Soriano |
| MGI ID: |
MGI:3850118 |
| Gene: |
Efnb1 Location: ChrX:98179736-98192597 bp, + strand Genetic Position: ChrX, 43.22 cM, cytoband D
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| Alliance: |
Efnb1tm4Sor page
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| Germline Transmission: |
Earliest citation of germline transmission:
J:150043
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| Parent Cell Line: |
AK7.1 (ES Cell)
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| Strain of Origin: |
129S4/SvJaeSor
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| Allele Type: |
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Targeted (Conditional ready, No functional change) |
| Mutations: |
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Insertion, Nucleotide substitutions
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Mutation details: An frt flanked neo cassette with a 3' loxP site was inserted downstream of exon 4. An additional loxP site was inserted downstream of exon 5 followed by a modified exon 5 in which all 6 intracellular tyrosines are replaced with phenylalanine and the last valine is deleted. Cre mediated removal of the wild-type exon 5 is needed to allow for expression of the modified exon 5.
(J:150043)
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| Mouse strains and cell lines
available from the International Mouse Strain Resource
(IMSR) |
| Carrying this Mutation: |
Mouse Strains: 0 strains available
Cell Lines: 0 lines available
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| Carrying any Efnb1 Mutation: |
15 strains or lines available
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| Original: |
J:150043 Bush JO, et al., Ephrin-B1 regulates axon guidance by reverse signaling through a PDZ-dependent mechanism. Genes Dev. 2009 Jul 1;23(13):1586-99 |
| All: |
1 reference(s) |
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Analysis Tools
