Summary | Mutation origin | Mutation description | Phenotypes | Find Mice (IMSR) | References

Symbol:	Efnb1tm2.2Sor
Name:	ephrin B1; targeted mutation 2.2, Philippe Soriano
MGI ID:	MGI:3850114
Synonyms:	Ephrin-B16F
Gene:	Efnb1  Location: ChrX:98179736-98192597 bp, + strand  Genetic Position: ChrX, 43.22 cM, cytoband D
Alliance:	Efnb1tm2.2Sor page

Germline Transmission:	Earliest citation of germline transmission: J:150043
Parent Cell Line:	AK7.1 (ES Cell)
Strain of Origin:	129S4/SvJaeSor

Allele Type:    Targeted Mutations:    Insertion, Nucleotide substitutions   Mutation details: Germ line, cre mediated recombination removed the wild-type exon 5 allowing for expression of the modified exon 5 in which all 6 intracellular tyrosines are replaced with phenylalanine. The protein product is predicted to lack the capacity for intracellular signalling. (J:150043)

View phenotypes and curated references for all genotypes (concatenated display).

Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:	Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Efnb1 Mutation:	15 strains or lines available

Original:	J:150043 Bush JO, et al., Ephrin-B1 regulates axon guidance by reverse signaling through a PDZ-dependent mechanism. Genes Dev. 2009 Jul 1;23(13):1586-99
All:	2 reference(s)