Summary | Mutation origin | Mutation description | Expression | Phenotypes | Find Mice (IMSR) | Notes | References

Symbol:	Gt(ROSA)26Sortm5(Etv4/en,-GFP)Amc
Name:	gene trap ROSA 26, Philippe Soriano; targeted mutation 5, Andrew P McMahon
MGI ID:	MGI:3848910
Synonyms:	R26-EtvEnR
Gene:	Gt(ROSA)26Sor  Location: Chr6:113044389-113054205 bp, - strand  Genetic Position: Chr6, 52.73 cM
Alliance:	Gt(ROSA)26Sortm5(Etv4/en,-GFP)Amc page

Germline Transmission:	Earliest citation of germline transmission: J:149478
Parent Cell Line:	Other (see notes) (ES Cell)
Strain of Origin:	129 and C57BL/6 and CBA and Swiss Webster

Allele Type:    Targeted (Conditional ready, Inserted expressed sequence, Reporter) Mutation:    Insertion   Gt(ROSA)26Sortm5(Etv4/en,-GFP)Amc expresses 1 gene Knock-in expresses: Organism Expressed Gene Note mouse Etv4 (MGI:99423)   Mutation details: A fusion of the mouse gene and sequence encoding the drosophila engrailed repressor element preceded by a floxed STOP/neo cassette and followed by an IRES-GFP was inserted into the locus. (J:149478)

View phenotypes and curated references for all genotypes (concatenated display).

In Mice Carrying this Mutation:

20 assay results

Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:	Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Gt(ROSA)26Sor Mutation:	942 strains or lines available

Original:	J:149478 Mao J, et al., Fgf-dependent Etv4/5 activity is required for posterior restriction of Sonic Hedgehog and promoting outgrowth of the vertebrate limb. Dev Cell. 2009 Apr;16(4):600-6
All:	4 reference(s)