Summary | Mutation origin | Mutation description | Expression | Phenotypes | Find Mice (IMSR) | References

Symbol:	Jag1tm1.1Loo
Name:	jagged 1; targeted mutation 1.1, Kathleen M Loomes
MGI ID:	MGI:3848155
Synonyms:	Jag1loxP
Gene:	Jag1  Location: Chr2:136923371-136958440 bp, - strand
Alliance:	Jag1tm1.1Loo page

Germline Transmission:	Earliest citation of germline transmission: J:149131
Parent Cell Line:	R1 (ES Cell)
Strain of Origin:	(129X1/SvJ x 129S1/Sv)F1-Kitl+

Allele Type:    Targeted (Conditional ready, No functional change) Mutation:    Insertion   Mutation details: A floxed neomycin cassette was placed upstream of exon 4 with an additional loxP site placed downstream of exon 5. The neomycin cassette was removed by transient expression of cre recombinase leaving exons 4 and 5 floxed. Exon 4 encodes the DSL region, which is conserved across species and is known to be crucial for ligand-receptor interactions. Deletion of exon 4 and exon 5 by cre recombinase was predicted to result in a frameshift mutation and premature truncation of the protein after 192 amino acids. (J:149131)

View phenotypes and curated references for all genotypes (concatenated display).

In Mice Carrying this Mutation:	114 assay results 1 RNA-Seq or microarray experiment(s)
In Structures Affected by this Mutation:	1 anatomical structure(s)

Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:	Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Jag1 Mutation:	76 strains or lines available

Original:	J:149131 Loomes KM, et al., Bile duct proliferation in liver-specific Jag1 conditional knockout mice: effects of gene dosage. Hepatology. 2007 Feb;45(2):323-30
All:	7 reference(s)