Summary | Mutation origin | Mutation description | Expression | Phenotypes | Disease models | Find Mice (IMSR) | References

Symbol:	Glis3tm1Amj
Name:	GLIS family zinc finger 3; targeted mutation 1, Anton M Jetten
MGI ID:	MGI:3848053
Synonyms:	Glis3deltaZF5, Glis3zf
Gene:	Glis3  Location: Chr19:28236251-28657477 bp, - strand  Genetic Position: Chr19, 22.88 cM
Alliance:	Glis3tm1Amj page

Germline Transmission:	Earliest citation of germline transmission: J:148994
Parent Cell Line:	Not Specified (ES Cell)
Strain of Origin:	129/Sv

Allele Type:    Targeted (Null/knockout) Mutations:    Insertion, Intragenic deletion   Mutation details: Exon 4, which contains the sequence coding for zinc finger 5, and parts of intron 3 and 4 were replaced with a neo cassette. Deletion of zinc finger 5 (ZF5) is predicted to disrupt DNA binding ablity and transcriptional activity of the gene. The inability of the protein produced from this allele to activate transcription of a luciferase reporter with a Glis-binding site was confirmed by cellular assay. (J:148994)

View phenotypes and curated references for all genotypes (concatenated display).

In Mice Carrying this Mutation:	3 RNA-Seq or microarray experiment(s)
In Structures Affected by this Mutation:	3 anatomical structure(s)

Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:	Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Glis3 Mutation:	40 strains or lines available

Original:	J:148994 Kang HS, et al., Glis3 is associated with primary cilia and Wwtr1/TAZ and implicated in polycystic kidney disease. Mol Cell Biol. 2009 May;29(10):2556-69
All:	4 reference(s)