Summary | Mutation origin | Mutation description | Expression | Phenotypes | Find Mice (IMSR) | References

Symbol:	Ccr6tm1Gma
Name:	C-C motif chemokine receptor 6; targeted mutation 1, Gabriel Marquez
MGI ID:	MGI:2179613
Synonyms:	CCR6-
Gene:	Ccr6  Location: Chr17:8454875-8475973 bp, + strand  Genetic Position: Chr17, 4.9 cM, cytoband A1
Alliance:	Ccr6tm1Gma page

Germline Transmission:	Earliest citation of germline transmission: J:68191
Parent Cell Line:	R1 (ES Cell)
Strain of Origin:	(129X1/SvJ x 129S1/Sv)F1-Kitl+

Allele Type:    Targeted (Null/knockout) Mutations:    Insertion, Intragenic deletion   Mutation details: A PGK-neomycin resistance cassette replaced most of the coding exon, leaving the sequences that encode the 25 carboxy terminal amino acids. Northern analysis of spleen and thymus did not detect mRNA in homozygous mutant mice. (J:68191)

View phenotypes and curated references for all genotypes (concatenated display).

In Structures Affected by this Mutation:

1 anatomical structure(s)

Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:	Mouse Strains: 3 strains available      Cell Lines: 0 lines available
Carrying any Ccr6 Mutation:	36 strains or lines available

Original:	J:68191 Varona R, et al., CCR6-deficient mice have impaired leukocyte homeostasis and altered contact hypersensitivity and delayed-type hypersensitivity responses. J Clin Invest. 2001 Mar;107(6):R37-45
All:	16 reference(s)