Summary | Mutation origin | Mutation description | Expression | Phenotypes | Find Mice (IMSR) | References

Symbol:	Prkar1atm2Gsm
Name:	protein kinase, cAMP dependent regulatory, type I, alpha; targeted mutation 2, G Stanley McKnight
MGI ID:	MGI:3845256
Synonyms:	RIalphaB
Gene:	Prkar1a  Location: Chr11:109540231-109560482 bp, + strand  Genetic Position: Chr11, 72.33 cM
Alliance:	Prkar1atm2Gsm page

Germline Transmission:	Earliest citation of germline transmission: J:148464
Parent Cell Line:	REK2 (ES Cell)
Strain of Origin:	129X1/SvJ

Allele Type:    Targeted (Conditional ready, Dominant negative) Mutations:    Insertion, Single point mutation   Mutation details: A point mutation results in the amino acid substitution of alanine for glycine at position 324 (G324A) encoded by exon 11. A floxed neo cassette upsteam of exon 11 prevents expression of the dominant negative mutation except following cre mediated removal of the cassette. (J:148464)

View phenotypes and curated references for all genotypes (concatenated display).

In Structures Affected by this Mutation:

10 anatomical structure(s)

Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:	Mouse Strains: 1 strain available      Cell Lines: 0 lines available
Carrying any Prkar1a Mutation:	19 strains or lines available

Original:	J:148464 Howe DG, et al., Inhibition of protein kinase A in murine enteric neurons causes lethal intestinal pseudo-obstruction. J Neurobiol. 2006 Feb 15;66(3):256-72
All:	8 reference(s)