Summary | Mutation origin | Mutation description | Expression | Phenotypes | Find Mice (IMSR) | References

Symbol:	Ptgs2tm1Gaf
Name:	prostaglandin-endoperoxide synthase 2; targeted mutation 1, Garret A FitzGerald
MGI ID:	MGI:3844713
Synonyms:	CM-COX-2, COX-2flox
Gene:	Ptgs2  Location: Chr1:149975851-149983978 bp, + strand  Genetic Position: Chr1, 63.84 cM, cytoband H1
Alliance:	Ptgs2tm1Gaf page

Germline Transmission:	Earliest citation of germline transmission: J:148331
Parent Cell Line:	Not Specified (ES Cell)
Strain of Origin:	Not Specified

Allele Type:    Targeted (Conditional ready, No functional change) Mutation:    Insertion   Mutation details: Exons 6, 7, and 8 that are critical for enzymatic function were flanked by loxP sites. PGE-2 production by activated peritoneal macrophages is unaffected in mice homozygous for this allele, indicating that gene function was not disrupted. (J:148331)

View phenotypes and curated references for all genotypes (concatenated display).

In Structures Affected by this Mutation:

4 anatomical structure(s)

Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:	Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Ptgs2 Mutation:	72 strains or lines available

Original:	J:148331 Wang D, et al., Cardiomyocyte cyclooxygenase-2 influences cardiac rhythm and function. Proc Natl Acad Sci U S A. 2009 May 5;106(18):7548-52
All:	17 reference(s)