Summary | Mutation origin | Mutation description | Expression | Phenotypes | Find Mice (IMSR) | References

Symbol: Khdc3tm1Dean Name: KH domain containing 3, subcortical maternal complex member; targeted mutation 1, Jurrien Dean MGI ID: MGI:3844604 Synonyms: Filiatm Gene: Khdc3  Location: Chr9:73009118-73011720 bp, + strand  Genetic Position: Chr9, 40.08 cM Alliance: Khdc3tm1Dean page

Impaired preimplantation development of Khdc3tm1Dean/Khdc3tm1Dean embryos Show the 4 phenotype image(s) involving this allele.

Germline Transmission:	Earliest citation of germline transmission: J:148330
Parent Cell Line:	Not Specified (ES Cell)
Strain of Origin:	129/Sv

Allele Type:    Targeted (Null/knockout) Mutations:    Insertion, Intragenic deletion   Mutation details: The first 2 exons including the transcription and translation start sites and part of the 5' UTR were replaced with a neo cassette via homologous recombination. Immunoblot analysis confirmed the absence of protein expression in ovaries from homozygous mice. (J:148330)

Generation of the Khdc3tm1Dean allele

View phenotypes and curated references for all genotypes (concatenated display).

In Structures Affected by this Mutation:

1 anatomical structure(s)

Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:	Mouse Strains: 1 strain available      Cell Lines: 0 lines available
Carrying any Khdc3 Mutation:	15 strains or lines available

Original:	J:148330 Zheng P, et al., Role of Filia, a maternal effect gene, in maintaining euploidy during cleavage-stage mouse embryogenesis. Proc Natl Acad Sci U S A. 2009 May 5;106(18):7473-8
All:	3 reference(s)