Summary | Mutation origin | Mutation description | Expression | Phenotypes | Find Mice (IMSR) | References

Symbol:	Onecut1tm1Flem
Name:	one cut domain, family member 1; targeted mutation 1, Frederic P Lemaigre
MGI ID:	MGI:2179340
Synonyms:	Hnf6-
Gene:	Onecut1  Location: Chr9:74769203-74796930 bp, + strand  Genetic Position: Chr9, 41.93 cM
Alliance:	Onecut1tm1Flem page

Germline Transmission:	Earliest citation of germline transmission: J:62595
Parent Cell Line:	R1 (ES Cell)
Strain of Origin:	(129X1/SvJ x 129S1/Sv)F1-Kitl+

Allele Type:    Targeted (Null/knockout) Mutations:    Insertion, Intragenic deletion   Mutation details: The proximal promoter region and exon 1 were replaced with a neomycin cassette via homologous recombination. Absence of gene expression in pancreas of homozygous mutant animals was verified by RT-PCR. (J:62595)

View phenotypes and curated references for all genotypes (concatenated display).

In Mice Carrying this Mutation:	225 assay results 2 RNA-Seq or microarray experiment(s)
In Structures Affected by this Mutation:	7 anatomical structure(s)

Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:	Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Onecut1 Mutation:	12 strains or lines available

Original:	J:62595 Jacquemin P, et al., Transcription factor hepatocyte nuclear factor 6 regulates pancreatic endocrine cell differentiation and controls expression of the proendocrine gene ngn3. Mol Cell Biol. 2000 Jun;20(12):4445-54
All:	28 reference(s)