Summary | Mutation origin | Mutation description | Expression | Phenotypes | Find Mice (IMSR) | References

Symbol:	Dag1tm2.1Kcam
Name:	dystroglycan 1; targeted mutation 2.1, Kevin P Campbell
MGI ID:	MGI:3841383
Synonyms:	DAG1lox, T30mN
Gene:	Dag1  Location: Chr9:108082060-108141176 bp, - strand  Genetic Position: Chr9, 59.08 cM
Alliance:	Dag1tm2.1Kcam page

Germline Transmission:	Earliest citation of germline transmission: J:156588
Parent Cell Line:	R1 (ES Cell)
Strain of Origin:	(129X1/SvJ x 129S1/Sv)F1-Kitl+

Allele Type:    Targeted (Conditional ready, No functional change) Mutations:    Insertion, Intragenic deletion   Mutation details: A targeting vector was used to introduce a loxP site downstream of exon 2 and insert a floxed neo cassette in the upstream intron. Cre mediated recombination removed the neomycin cassette, leaving a loxP site in intron 1 and another 3' to the 3' UTR. (J:78838, J:156588)

View phenotypes and curated references for all genotypes (concatenated display).

In Structures Affected by this Mutation:

1 anatomical structure(s)

Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:	Mouse Strains: 1 strain available      Cell Lines: 0 lines available
Carrying any Dag1 Mutation:	109 strains or lines available

Original:	J:156588 Campbell K, Mice homozygous for a dystroglycan 1 mutation with exon flanked by loxP sites are viable and fertile and appear healthy. MGI Direct Data Submission. 2010;
All:	8 reference(s)