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Fostm3.1Wag
Targeted Allele Detail
Summary
Symbol: Fostm3.1Wag
Name: FBJ osteosarcoma oncogene; targeted mutation 3.1, Erwin F Wagner
MGI ID: MGI:5142238
Synonyms: Fos362A
Gene: Fos  Location: Chr12:85520664-85524047 bp, + strand  Genetic Position: Chr12, 39.7 cM
Alliance: Fostm3.1Wag page
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:175064
Parent Cell Line:  HM-1 (ES Cell)
Strain of Origin:  129P2/OlaHsd-Hprt1b-m3
Mutation
description
Allele Type:    Targeted (Reporter)
Mutations:    Insertion, Nucleotide substitutions
 
Mutation detailsExon 4 was replaced with a modified exon in which nucleotide substitutions result in the amino acid substitution of alanine for serine at position 362 (S362A). Flp-mediated recombination removed the floxed neo cassette inserted downstream of the endogenous polyadenylation sequence and left an EGFP gene with a 5' loxP site intact. (J:175064)
Phenotypes
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View phenotypes and curated references for all genotypes (concatenated display).
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Fos Mutation:  42 strains or lines available
References
Original:  J:175064 Bakiri L, et al., Functions of Fos phosphorylation in bone homeostasis, cytokine response and tumourigenesis. Oncogene. 2011 Mar 31;30(13):1506-17
All:  1 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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last database update
03/19/2024
MGI 6.23
The Jackson Laboratory