Summary | Mutation origin | Mutation description | Expression | Phenotypes | Find Mice (IMSR) | References

Symbol:	Ccn2tm1Mga
Name:	cellular communication network factor 2; targeted mutation 1, Maureen Gannon
MGI ID:	MGI:3840270
Synonyms:	CTGFlacZ
Gene:	Ccn2  Location: Chr10:24471340-24474581 bp, + strand  Genetic Position: Chr10, 11.84 cM, cytoband A3-B1
Alliance:	Ccn2tm1Mga page

Germline Transmission:	Earliest citation of germline transmission: J:145696
Parent Cell Line:	F1H4 (ES Cell)
Strain of Origin:	(129S6/SvEvTac x C57BL/6NTac)F1

Allele Type:    Targeted (Null/knockout, Reporter) Mutations:    Insertion, Intragenic deletion   Mutation details: The gene was disrupted by replacement of exons 3, 4 and a part of exon 5 coding for von Willebrand factor type C domain with a transmembrane domain-lacZ/neo cassette via homologous recombination. The neo selection minigene was flanked with LoxP sites. Resulting allele produces a Ctgf N terminus/beta-gal fusion protein. (J:145696, J:200671)

View phenotypes and curated references for all genotypes (concatenated display).

In Structures Affected by this Mutation:

6 anatomical structure(s)

Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:	Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Ccn2 Mutation:	27 strains or lines available

Original:	J:145696 Crawford LA, et al., Connective Tissue Growth Factor (CTGF) Inactivation Leads to Defects in Islet Cell Lineage Allocation and {beta}-Cell Proliferation during Embryogenesis. Mol Endocrinol. 2009 Mar;23(3):324-36
All:	5 reference(s)