Slc6a9tm1.1Caz
Targeted Allele Detail
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Symbol: |
Slc6a9tm1.1Caz |
Name: |
solute carrier family 6 (neurotransmitter transporter, glycine), member 9; targeted mutation 1.1, Chiara Cazzin |
MGI ID: |
MGI:5085299 |
Synonyms: |
Glyt1 lox |
Gene: |
Slc6a9 Location: Chr4:117692240-117726502 bp, + strand Genetic Position: Chr4, 53.62 cM
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Alliance: |
Slc6a9tm1.1Caz page
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Germline Transmission: |
Earliest citation of germline transmission:
J:168155
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Parent Cell Line: |
E14.1 (ES Cell)
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Strain of Origin: |
129P2/OlaHsd
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Allele Type: |
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Targeted (Conditional ready, No functional change) |
Mutations: |
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Insertion, Intragenic deletion
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Mutation details: A loxP site within intron 2 and the neomycin cassette flanked by Frt sites and an additional loxP site within intron
3 are inserted by homologous recombination. The conditional allele was generated by breeding with a germline Flp deleter strain Gt(ROSA)26Sor to delete the Neo cassette leaving a single loxP and Frt sites in intron 3. Although the cre-mediated deletion is predicted to result in the production of an in-frame transcript, the gene product from this allele is predicted to be non functional.
(J:168155)
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Mouse strains and cell lines
available from the International Mouse Strain Resource
(IMSR) |
Carrying this Mutation: |
Mouse Strains: 0 strains available
Cell Lines: 0 lines available
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Carrying any Slc6a9 Mutation: |
24 strains or lines available
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Original: |
J:168155 Cazzin C, et al., Adenoviral-mediated Cre expression effectively suppresses GlyT1 binding in the thalamic area of GlyT1 conditional knock-out mice. J Neurosci Methods. 2010 Nov 30;193(2):254-63 |
All: |
1 reference(s) |
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