Summary | Mutation origin | Mutation description | Phenotypes | Find Mice (IMSR) | References

Symbol:	Pik3r5tm1Lste
Name:	phosphoinositide-3-kinase regulatory subunit 5; targeted mutation 1, Len Stephens
MGI ID:	MGI:3840090
Synonyms:	p101-
Gene:	Pik3r5  Location: Chr11:68322951-68388675 bp, + strand  Genetic Position: Chr11, 41.69 cM
Alliance:	Pik3r5tm1Lste page

Germline Transmission:	Earliest citation of germline transmission: J:147259
Parent Cell Line:	E14 (ES Cell)
Strain of Origin:	129P2/OlaHsd

Allele Type:    Targeted (Null/knockout) Mutations:    Insertion, Intragenic deletion   Mutation details: A BamHI restriction site was engineered at codon 11 in exon 1 and used to insert a beta galactosidase-neomycin selection cassette. This caused the deletion of exons 2 and 3 as well. Neutrophiles have no detectable protein. (J:147259)

View phenotypes and curated references for all genotypes (concatenated display).

Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:	Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Pik3r5 Mutation:	49 strains or lines available

Original:	J:147259 Suire S, et al., Gbetagammas and the Ras binding domain of p110gamma are both important regulators of PI(3)Kgamma signalling in neutrophils. Nat Cell Biol. 2006 Nov;8(11):1303-9
All:	3 reference(s)