Summary | Mutation origin | Mutation description | Phenotypes | Find Mice (IMSR) | References

Symbol:	Gt(ROSA)26Sortm1(Actb-Met)Fmai
Name:	gene trap ROSA 26, Philippe Soriano; targeted mutation 1, Flavio Maina
MGI ID:	MGI:5052130
Synonyms:	Gt(ROSA)26Sortm1(Actb-Met)Pali, Mettg, Rosa26LacZ-stop-Met
Gene:	Gt(ROSA)26Sor  Location: Chr6:113044389-113054205 bp, - strand  Genetic Position: Chr6, 52.73 cM
Alliance:	Gt(ROSA)26Sortm1(Actb-Met)Fmai page

Germline Transmission:	Earliest citation of germline transmission: J:173661
Parent Cell Line:	R1 (ES Cell)
Strain of Origin:	(129X1/SvJ x 129S1/Sv)F1-Kitl+

Allele Type:    Targeted (Conditional ready, Inserted expressed sequence) Mutation:    Insertion   Gt(ROSA)26Sortm1(Actb-Met)Fmai expresses 1 gene Knock-in expresses: Organism Expressed Gene Note mouse Met (MGI:96969)   Mutation details: The targeting construct was compased of a Met gene located downstream of a CMV enhancer beta actin promoter and a floxed stop cassette. Met expression requires cre excision of the stop cassette. (J:173661, J:220592)

View phenotypes and curated references for all genotypes (concatenated display).

Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:	Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Gt(ROSA)26Sor Mutation:	942 strains or lines available

Original:	J:173661 Tonges L, et al., Hepatocyte growth factor protects retinal ganglion cells by increasing neuronal survival and axonal regeneration in vitro and in vivo. J Neurochem. 2011 Jun;117(5):892-903
All:	7 reference(s)