Summary | Mutation origin | Mutation description | Phenotypes | Find Mice (IMSR) | References

Symbol:	Mre11atm2.2Dof
Name:	MRE11A homolog A, double strand break repair nuclease; targeted mutation 2.2, David O Ferguson
MGI ID:	MGI:3839940
Synonyms:	Mre11delta
Gene:	Mre11a  Location: Chr9:14695971-14748421 bp, + strand  Genetic Position: Chr9, 4.33 cM
Alliance:	Mre11atm2.2Dof page

Germline Transmission:	Earliest citation of germline transmission: J:147247
Parent Cell Line:	Not Specified (ES Cell)
Strain of Origin:	Not Specified

Allele Type:    Targeted (Null/knockout) Mutations:    Insertion, Intragenic deletion   Mutation details: Germ line, cre mediated recombination was used to remove the neo cassette and exon 5. This deletion causes a frame shift and generates multiple stop codons after eight amino acids. The absence of protein expression was confirmed in mouse embryonic fibroblast extracts. (J:147247)

View phenotypes and curated references for all genotypes (concatenated display).

Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:	Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Mre11a Mutation:	48 strains or lines available

Original:	J:147247 Buis J, et al., Mre11 nuclease activity has essential roles in DNA repair and genomic stability distinct from ATM activation. Cell. 2008 Oct 3;135(1):85-96
All:	3 reference(s)