Summary | Mutation origin | Mutation description | Expression | Phenotypes | Find Mice (IMSR) | References

Symbol:	Smad3tm1Sche
Name:	SMAD family member 3; targeted mutation 1, Sheldon Chen
MGI ID:	MGI:3839291
Gene:	Smad3  Location: Chr9:63554049-63665276 bp, - strand  Genetic Position: Chr9, 34.22 cM, cytoband D
Alliance:	Smad3tm1Sche page

Germline Transmission:	Earliest citation of germline transmission: J:145114
Parent Cell Line:	E14.1 (ES Cell)
Strain of Origin:	129P2/OlaHsd

Allele Type:    Targeted (Null/knockout) Mutations:    Insertion, Intragenic deletion   Mutation details: Exons 2 and 3 were replaced with a neo cassette. The absence of protein expression was confirmed by western blot analysis on kidney extracts. (J:145114)

View phenotypes and curated references for all genotypes (concatenated display).

In Structures Affected by this Mutation:

5 anatomical structure(s)

Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:	Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Smad3 Mutation:	18 strains or lines available

Original:	J:145114 Wang A, et al., Interference with TGF-beta signaling by Smad3-knockout in mice limits diabetic glomerulosclerosis without affecting albuminuria. Am J Physiol Renal Physiol. 2007 Nov;293(5):F1657-65
All:	1 reference(s)