Summary | Mutation origin | Mutation description | Expression | Phenotypes | Find Mice (IMSR) | References

Symbol: Lrp5tm3.2Mawa Name: low density lipoprotein receptor-related protein 5; targeted mutation 3.2, Matthew Warman MGI ID: MGI:5014217 Gene: Lrp5  Location: Chr19:3634828-3736564 bp, - strand  Genetic Position: Chr19, 3.33 cM, cytoband B Alliance: Lrp5tm3.2Mawa page

Analysis of bone mass in Lrp5tm3.2Mawa/Lrp5tm3.2Mawa, Hivep3tm1Glm/Hivep3tm1Glm, and double mutant mice Show the 1 phenotype image(s) involving this allele.

Germline Transmission:	Earliest citation of germline transmission: J:172746
Parent Cell Line:	CJ7 (ES Cell)
Strain of Origin:	129S1/Sv-Oca2+ Tyr+ Kitl+

Allele Type:    Targeted (Null/knockout) Mutation:    Insertion   Mutation details: A loxP site was inserted upstream of exon 2 and a loxP site and FRT flanked inverted neo cassette were inserted downstream of exon 2 via homologous recombination. Flp mediated recombination removed the neo cassette. Cre mediated recombination removed exon 2. (J:172746)

View phenotypes and curated references for all genotypes (concatenated display).

In Structures Affected by this Mutation:

1 anatomical structure(s)

Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:	Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Lrp5 Mutation:	81 strains or lines available

Original:	J:172746 Cui Y, et al., Lrp5 functions in bone to regulate bone mass. Nat Med. 2011 Jun;17(6):684-91
All:	2 reference(s)