Summary | Mutation origin | Mutation description | Find Mice (IMSR) | References

Symbol:	Gt(ROSA)26Sortm1(CBR,hMGFP)Dpiw
Name:	gene trap ROSA 26, Philippe Soriano; targeted mutation 1, David Piwnica-Worms
MGI ID:	MGI:5009465
Synonyms:	Gt(ROSA)26Sortm1(CBR,hMGFP)Rko, RosaCBR
Gene:	Gt(ROSA)26Sor  Location: Chr6:113044389-113054205 bp, - strand  Genetic Position: Chr6, 52.73 cM
Alliance:	Gt(ROSA)26Sortm1(CBR,hMGFP)Dpiw page

Germline Transmission:	Earliest citation of germline transmission: J:171829
Parent Cell Line:	Not Specified (ES Cell)
Strain of Origin:	Not Specified

Allele Type:    Targeted (Conditional ready, Reporter) Mutation:    Insertion   Mutation details: The targeting vector contained cDNA coding for a fusion protein of click beetle red (CBR)luciferase and monster GFP (hMGFP), preceded by a floxed stop cassette. The construct was targeted to the Gt(ROSA)26Sor locus in ES cells. Cre excision of the stop cassette in knock-in animals results in activation of the CBR reporter. (J:171829)

Generation of the Gt(ROSA)26Sortm1(CBR,hMGFP)Dpiw allele

Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:	Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Gt(ROSA)26Sor Mutation:	942 strains or lines available

Original:	J:171829 Liu Z, et al., Notch1 loss of heterozygosity causes vascular tumors and lethal hemorrhage in mice. J Clin Invest. 2011 Feb 1;121(2):800-8
All:	1 reference(s)