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Rr162tm3.1Wtg
Targeted Allele Detail
Summary
Symbol: Rr162tm3.1Wtg
Name: regulatory region 162; targeted mutation 3.1, William T Garrard
MGI ID: MGI:5009316
Synonyms: Igktm3.1Wtg, Sis-
Gene: Rr162  Location: unknown  Genetic Position: Chr6, Syntenic
Alliance: Rr162tm3.1Wtg page
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:172855
Parent Cell Line:  SM1 (ES Cell)
Strain of Origin:  129S6/SvEvTac
Mutation
description
Allele Type:    Targeted (Modified regulatory region)
Mutations:    Insertion, Intergenic deletion
 
Mutation detailsA 3.7 kb region containing the silencer in the Vkappa-Jkappa intervening sequence (Sis) was flanked with a loxP site on one side and a loxP site flanked neomycin resistance gene cassette on the other. Cre-mediated recombination removed the neo cassette and Sis. (J:172855)
Phenotypes
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View phenotypes and curated references for all genotypes (concatenated display).
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Rr162 Mutation:  0 strains or lines available
References
Original:  J:172855 Xiang Y, et al., A multifunctional element in the mouse Igkappa locus that specifies repertoire and Ig loci subnuclear location. J Immunol. 2011 May 1;186(9):5356-66
All:  1 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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last database update
03/19/2024
MGI 6.23
The Jackson Laboratory