Summary | Mutation origin | Mutation description | Expression | Phenotypes | Find Mice (IMSR) | References

Symbol:	Adamts4tm1.1Boer
Name:	ADAM metallopeptidase with thrombospondin type 1 motif 4; targeted mutation 1.1, Derek Boerboom
MGI ID:	MGI:5009124
Synonyms:	Adamts4-
Gene:	Adamts4  Location: Chr1:171077990-171088206 bp, + strand  Genetic Position: Chr1, 79.28 cM
Alliance:	Adamts4tm1.1Boer page

Germline Transmission:	Earliest citation of germline transmission: J:172645
Parent Cell Line:	R1 (ES Cell)
Strain of Origin:	(129X1/SvJ x 129S1/Sv)F1-Kitl+

Allele Type:    Targeted (Null/knockout) Mutations:    Insertion, Intragenic deletion   Mutation details: A loxP site was inserted upstream of exon 2 and a loxP site and FRT flanked neo cassette were inserted downstream of exon 3 via homologous recombination. Cre mediated recombination removed exons 2 and 3. (J:172645)

View phenotypes and curated references for all genotypes (concatenated display).

In Mice Carrying this Mutation:

18 assay results

Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:	Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Adamts4 Mutation:	48 strains or lines available

Original:	J:172645 Boerboom D, et al., Partially redundant functions of Adamts1 and Adamts4 in the perinatal development of the renal medulla. Dev Dyn. 2011 Jul;240(7):1806-14
All:	2 reference(s)