Summary | Mutation origin | Mutation description | Expression | Phenotypes | Disease models | Find Mice (IMSR) | References

Symbol:	Ncstntm1.1Akli
Name:	nicastrin; targeted mutation 1.1, Apostolos Klinakis
MGI ID:	MGI:5009035
Synonyms:	Ncstnf
Gene:	Ncstn  Location: Chr1:171893580-171910356 bp, - strand  Genetic Position: Chr1, 79.54 cM
Alliance:	Ncstntm1.1Akli page

Germline Transmission:	Earliest citation of germline transmission: J:172442
Parent Cell Line:	Not Specified (ES Cell)
Strain of Origin:	129

Allele Type:    Targeted (Conditional ready, No functional change) Mutation:    Insertion   Mutation details: An FRT flanked pgk-neo cassette and loxP sit were inserted into intron 4 and a loxP site was inserted into intron 7 via homologous recombination. Flp mediated recombination removed the pgk-neo cassette leaving exons 5-7 floxed. (J:172442)

View phenotypes and curated references for all genotypes (concatenated display).

In Structures Affected by this Mutation:

4 anatomical structure(s)

Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:	Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Ncstn Mutation:	33 strains or lines available

Original:	J:172442 Klinakis A, et al., A novel tumour-suppressor function for the Notch pathway in myeloid leukaemia. Nature. 2011 May 12;473(7346):230-3
All:	7 reference(s)