Summary | Mutation origin | Mutation description | Phenotypes | Find Mice (IMSR) | References

Symbol:	Lrrk2tm2Mjfa
Name:	leucine-rich repeat kinase 2; targeted mutation 2, Matthew Farrer
MGI ID:	MGI:5008466
Gene:	Lrrk2  Location: Chr15:91557378-91700323 bp, + strand  Genetic Position: Chr15, 46.07 cM, cytoband F1
Alliance:	Lrrk2tm2Mjfa page

Germline Transmission:	Earliest citation of germline transmission: J:172418
Parent Cell Line:	Not Specified (ES Cell)
Strain of Origin:	Not Specified

Allele Type:    Targeted (Not Specified) Mutations:    Insertion, Nucleotide substitutions   Mutation details: Nucleotide substitutions (GGG to AGC) in exon 41 results in the amino acid substitution of serine for glycine at position 2019 (G2019S). Cre-mediated recombination removed the selection cassette. (J:172418, J:242269)

View phenotypes and curated references for all genotypes (concatenated display).

Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:	Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Lrrk2 Mutation:	156 strains or lines available

Original:	J:172418 Dachsel JC, et al., A comparative study of Lrrk2 function in primary neuronal cultures. Parkinsonism Relat Disord. 2010 Dec;16(10):650-5
All:	2 reference(s)