Summary | Mutation origin | Mutation description | Expression | Phenotypes | Find Mice (IMSR) | References

Symbol:	Arnt2tm1Yfk
Name:	aryl hydrocarbon receptor nuclear translocator 2; targeted mutation 1, Yoshiaki Fujii-Kuriyama
MGI ID:	MGI:2178831
Synonyms:	Arnt2-
Gene:	Arnt2  Location: Chr7:83895486-84059201 bp, - strand  Genetic Position: Chr7, 48.35 cM
Alliance:	Arnt2tm1Yfk page

Germline Transmission:	Earliest citation of germline transmission: J:74118
Parent Cell Line:	E14 (ES Cell)
Strain of Origin:	129P2/OlaHsd

Allele Type:    Targeted (Null/knockout) Mutation:    Insertion   Mutation details: An in-frame NLS-LacZ cassette was introduced into this gene via homologous recombination, disrupting the HLH domain which is involved in dimerization and DNA binding. Successful homologous recombination was confirmed by Southern blotting. Protein was not present in brain of neonate homozygous mutant animals via immunohistochemistry analysis. (J:74118)

View phenotypes and curated references for all genotypes (concatenated display).

In Structures Affected by this Mutation:

5 anatomical structure(s)

Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:	Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Arnt2 Mutation:	37 strains or lines available

Original:	J:74118 Hosoya T, et al., Defective development of secretory neurones in the hypothalamus of Arnt2-knockout mice. Genes Cells. 2001 Apr;6(4):361-74
All:	1 reference(s)