Summary | Mutation origin | Mutation description | Expression | Phenotypes | Find Mice (IMSR) | References

Symbol: Notch1sot Name: notch 1; sottile tubo MGI ID: MGI:5004944 Gene: Notch1  Location: Chr2:26347914-26393834 bp, - strand  Genetic Position: Chr2, 18.91 cM Alliance: Notch1sot page

Thin neural tube in E9.5-10.5 Notch1sot/Notch1sot embryos Show the 4 phenotype image(s) involving this allele.

Strain of Origin:

129S1/Sv or C57BL/6

Allele Type:    Chemically induced (ENU) Mutation:    Single point mutation   Mutation details: A T-to-A base pair change creates an early stop codon and is predicted to truncate the normally 2531 amino acid protein to 84 amino acids. (J:171522)

View phenotypes and curated references for all genotypes (concatenated display).

In Structures Affected by this Mutation:

3 anatomical structure(s)

Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:	Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Notch1 Mutation:	115 strains or lines available

Original:	J:171522 Sandell LL, et al., A phenotype-driven ENU mutagenesis screen identifies novel alleles with functional roles in early mouse craniofacial development. Genesis. 2011 Apr;49(4):342-59
All:	1 reference(s)