Summary | Mutation origin | Mutation description | Expression | Phenotypes | Find Mice (IMSR) | References

Symbol:	Thrbtm1Mkni
Name:	thyroid hormone receptor beta; targeted mutation 1, Marlies Knipper
MGI ID:	MGI:3836780
Synonyms:	Thrbtm1.1Sasr, TRbetaflox, TRbeta L2, TRbetalox
Gene:	Thrb  Location: Chr14:4431611-4809435 bp, - strand  Genetic Position: Chr14, 7.08 cM, cytoband A3
Alliance:	Thrbtm1Mkni page

Germline Transmission:	Earliest citation of germline transmission: J:145941
Parent Cell Line:	Not Specified (ES Cell)
Strain of Origin:	Not Specified

Allele Type:    Targeted (Conditional ready, No functional change) Mutation:    Insertion   Mutation details: LoxP sites were introduced 5' and 3' of exon 8 and an FRT site flanked neomycin resistance gene cassette was introduced downstream of the 3' loxP site in intron 8. The neo cassette was then removed by Flp-mediated recombination leaving behind a single FRT site. (J:145941)

View phenotypes and curated references for all genotypes (concatenated display).

In Mice Carrying this Mutation:	44 assay results 1 RNA-Seq or microarray experiment(s)
In Structures Affected by this Mutation:	2 anatomical structure(s)

Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:	Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Thrb Mutation:	39 strains or lines available

Original:	J:145941 Winter H, et al., Deafness in TRbeta mutants is caused by malformation of the tectorial membrane. J Neurosci. 2009 Feb 25;29(8):2581-7
All:	13 reference(s)