Summary | Mutation origin | Mutation description | Expression | Phenotypes | Find Mice (IMSR) | References

Symbol:	Itktm1Litt
Name:	IL2 inducible T cell kinase; targeted mutation 1, Dan R Littman
MGI ID:	MGI:2178820
Synonyms:	itk-, Itktm1Drl
Gene:	Itk  Location: Chr11:46215977-46280342 bp, - strand  Genetic Position: Chr11, 27.75 cM
Alliance:	Itktm1Litt page

Germline Transmission:	Earliest citation of germline transmission: J:31230
Parent Cell Line:	J1 (ES Cell)
Strain of Origin:	129S4/SvJae

Allele Type:    Targeted (Null/knockout) Mutations:    Insertion, Intragenic deletion   Mutation details: Exon 4 and part of exon 3 of this gene was replaced with a PGK(G)neopA cassette via homologous recombination. A stop codon was engineered at position 78 to further ensure a null allele. PCR and Southern blot analysis confirmed the presence of the targeted mutation, and Western blot analysis determined no Itk protein was present in thymocytes of homozygous mutant animals. (J:31230)

View phenotypes and curated references for all genotypes (concatenated display).

In Structures Affected by this Mutation:

1 anatomical structure(s)

Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:	Mouse Strains: 2 strains available      Cell Lines: 0 lines available
Carrying any Itk Mutation:	48 strains or lines available

Original:	J:31230 Liao XC, et al., Altered T cell receptor signaling and disrupted T cell development in mice lacking Itk. Immunity. 1995 Dec;3(6):757-69
All:	53 reference(s)