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Sox18tm1Koop
Targeted Allele Detail
Summary
Symbol: Sox18tm1Koop
Name: SRY (sex determining region Y)-box 18; targeted mutation 1, Peter Koopman
MGI ID: MGI:2178809
Synonyms: Sox18-
Gene: Sox18  Location: Chr2:181311630-181313433 bp, - strand  Genetic Position: Chr2, 103.71 cM
Alliance: Sox18tm1Koop page
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:66010
Parent Cell Line:  R1 (ES Cell)
Strain of Origin:  (129X1/SvJ x 129S1/Sv)F1-Kitl+
Mutation
description
Allele Type:    Targeted (Null/knockout, Reporter)
Mutations:    Insertion, Intragenic deletion
 
Mutation detailsThe gene was disrupted by replacing sequences encoding the HMG box with a LoxP-neo-LacZ cassette via homologous recombination. RT-PCR analysis of mutant embryos confirmed transcripts of the HMG coding region were absent although transcripts of the trans-activating domain downstream of the LoxP-neo-LacZ cassette were present. (J:66010)
Phenotypes
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View phenotypes and curated references for all genotypes (concatenated display).
Expression
In Mice Carrying this Mutation: 24 assay results
In Structures Affected by this Mutation: 3 anatomical structure(s)
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Sox18 Mutation:  25 strains or lines available
References
Original:  J:66010 Pennisi D, et al., Mice null for sox18 are viable and display a mild coat defect. Mol Cell Biol. 2000 Dec;20(24):9331-6
All:  11 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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last database update
03/19/2024
MGI 6.23
The Jackson Laboratory