Summary | Mutation origin | Mutation description | Expression | Phenotypes | Find Mice (IMSR) | References

Symbol:	Otx2tm4.1Sia
Name:	orthodenticle homeobox 2; targeted mutation 4.1, Shinichi Aizawa
MGI ID:	MGI:2178753
Synonyms:	Otx2flox, Otx2/flox
Gene:	Otx2  Location: Chr14:48894238-48905101 bp, - strand  Genetic Position: Chr14, 25.36 cM
Alliance:	Otx2tm4.1Sia page

Germline Transmission:	Earliest citation of germline transmission: J:74631
Parent Cell Line:	TT2 (ES Cell)
Strain of Origin:	(C57BL/6NCrlj x CBA/JNCrlj)F1

Allele Type:    Targeted (Conditional ready, No functional change) Mutation:    Insertion   Mutation details: This allele is a derivative of Otx2tm4Sia in which the neomycin resistance cassette was removed by crossing mice carrying the Otx2tm4Sia allele to mice expressing Flp recombinase in the germline. The final allele carries a single frt site in place of the frt-flanked neomycin cassette. (J:74631)

View phenotypes and curated references for all genotypes (concatenated display).

In Mice Carrying this Mutation:

2 RNA-Seq or microarray experiment(s)

Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:	Mouse Strains: 1 strain available      Cell Lines: 0 lines available
Carrying any Otx2 Mutation:	50 strains or lines available

Original:	J:74631 Tian E, et al., Otx2 is required to respond to signals from anterior neural ridge for forebrain specification. Dev Biol. 2002 Feb 15;242(2):204-23
All:	15 reference(s)