Summary | Mutation origin | Mutation description | Phenotypes | Find Mice (IMSR) | References

Symbol:	Gt(ROSA)26Sortm1(Tcfe2a/Tal1)Xhsu
Name:	gene trap ROSA 26, Philippe Soriano; targeted mutation 1, Xiao-Hong Sun
MGI ID:	MGI:3833549
Synonyms:	ET2
Gene:	Gt(ROSA)26Sor  Location: Chr6:113044389-113054205 bp, - strand  Genetic Position: Chr6, 52.73 cM
Alliance:	Gt(ROSA)26Sortm1(Tcfe2a/Tal1)Xhsu page

Germline Transmission:	Earliest citation of germline transmission: J:144569
Parent Cell Line:	Not Specified (ES Cell)
Strain of Origin:	129X1/SvJ

Allele Type:    Targeted (Conditional ready, Inserted expressed sequence, Reporter) Mutation:    Insertion   Mutation details: A selection marker and a transcriptional stop cassette were flanked by loxP sites and placed upstream of a chimeric gene. This chimeric gene encodes the transactivation domains of Tcfe2a (E47) and the bHLH domain of Tal1 (SCL). An IRES-GFP cassette was placed downstream of the chimeric gene and the whole construct (loxP-neo-STOP-loxp- Tcfe2a/Tal1-IRES-GFP) was knocked into the locus. Upon expression of cre recombinase, the chimeric protein and GFP will be expressed, with the chimeric protein predicted to have a dominant negative effect on members of the Id and Tal protein family due to its strong affinity for E transcription factors. (J:144569)

View phenotypes and curated references for all genotypes (concatenated display).

Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:	Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Gt(ROSA)26Sor Mutation:	942 strains or lines available

Original:	J:144569 Cochrane SW, et al., Balance between Id and E proteins regulates myeloid-versus-lymphoid lineage decisions. Blood. 2009 Jan 29;113(5):1016-26
All:	3 reference(s)