Summary | Mutation origin | Mutation description | Phenotypes | Find Mice (IMSR) | References

Symbol:	Fktntm3(FKTN)Ttd
Name:	fukutin; targeted mutation 3, Tatsushi Toda
MGI ID:	MGI:3832562
Synonyms:	FtknHn
Gene:	Fktn  Location: Chr4:53713745-53765785 bp, + strand  Genetic Position: Chr4, 28.74 cM
Alliance:	Fktntm3(FKTN)Ttd page

Germline Transmission:	Earliest citation of germline transmission: J:144746
Parent Cell Line:	Not Specified (ES Cell)
Strain of Origin:	Not Specified

Allele Type:    Targeted (Humanized sequence, Inserted expressed sequence) Mutations:    Insertion, Intragenic deletion   Mutation details: Exon 10 was removed from the locus via Cre mediated expression following the insertion of lox71 and loxP sites. Wild-type human FKTN exon 10 cDNA was inserted into the locus between lox66 and loxP sites of the targeting construct. (J:144746)

View phenotypes and curated references for all genotypes (concatenated display).

Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:	Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Fktn Mutation:	44 strains or lines available

Original:	J:144746 Kanagawa M, et al., Residual laminin-binding activity and enhanced dystroglycan glycosylation by LARGE in novel model mice to dystroglycanopathy. Hum Mol Genet. 2009 Feb 15;18(4):621-31
All:	2 reference(s)