Summary | Mutation origin | Mutation description | Expression | Phenotypes | Tumor data | Find Mice (IMSR) | References

Symbol:	Tgfbitm1Zhao
Name:	transforming growth factor, beta induced; targeted mutation 1, Yongliang Zhao
MGI ID:	MGI:3830817
Gene:	Tgfbi  Location: Chr13:56757399-56787172 bp, + strand  Genetic Position: Chr13, 30.09 cM, cytoband B-C1
Alliance:	Tgfbitm1Zhao page

Germline Transmission:	Earliest citation of germline transmission: J:143036
Parent Cell Line:	Not Specified (ES Cell)
Strain of Origin:	129/Sv

Allele Type:    Targeted (Null/knockout) Mutations:    Insertion, Intragenic deletion   Mutation details: Exons 4 through 6 were replaced with a neo cassette. The absence of protein expression was confirmed by western blot analysis on mouse embryonic fibrolasts. (J:143036)

View phenotypes and curated references for all genotypes (concatenated display).

In Structures Affected by this Mutation:

3 anatomical structure(s)

List all tumor models in MMHCdb carrying Tgfbitm1Zhao

Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:	Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Tgfbi Mutation:	34 strains or lines available

Original:	J:143036 Zhang Y, et al., TGFBI deficiency predisposes mice to spontaneous tumor development. Cancer Res. 2009 Jan 1;69(1):37-44
All:	2 reference(s)