Summary | Mutation origin | Mutation description | Expression | Phenotypes | Find Mice (IMSR) | References

Symbol:	Twsg1tm1.1Mboc
Name:	twisted gastrulation BMP signaling modulator 1; targeted mutation 1.1, Michael B O'Connor
MGI ID:	MGI:3830633
Synonyms:	Twsg1-
Gene:	Twsg1  Location: Chr17:66230060-66258198 bp, - strand  Genetic Position: Chr17, 35.26 cM
Alliance:	Twsg1tm1.1Mboc page

Germline Transmission:	Earliest citation of germline transmission: J:88784
Parent Cell Line:	AB1 (ES Cell)
Strain of Origin:	129S7/SvEvBrd-Hprt1+

Allele Type:    Targeted (Null/knockout) Mutations:    Insertion, Intragenic deletion   Mutation details: An Frt flanked PGK-neomycin cassette with a 3' loxP site was inserted in intron 2. A second loxP site was inserted 3' to exon 3. These mice were crossed to mice carrying Tg(ACTB-cre)2Mrt in order to excise exon 3. Mice resulting from this cross express a truncated message. Presence or absence of the PGK neo cassette has no affect on phenotype. (J:88784)

View phenotypes and curated references for all genotypes (concatenated display).

In Mice Carrying this Mutation:	42 assay results
In Structures Affected by this Mutation:	16 anatomical structure(s)

Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:	Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Twsg1 Mutation:	20 strains or lines available

Original:	J:88784 Petryk A, et al., The mammalian twisted gastrulation gene functions in foregut and craniofacial development. Dev Biol. 2004 Mar 15;267(2):374-86
All:	7 reference(s)