Summary | Mutation origin | Mutation description | Expression | Phenotypes | Find Mice (IMSR) | References

Symbol:	Lrp1tm1Ajmr
Name:	low density lipoprotein receptor-related protein 1; targeted mutation 1, Anton J M Roebroek
MGI ID:	MGI:3830336
Gene:	Lrp1  Location: Chr10:127374030-127457017 bp, - strand  Genetic Position: Chr10, 74.52 cM, cytoband B2-D1
Alliance:	Lrp1tm1Ajmr page

Germline Transmission:	Earliest citation of germline transmission: J:144146
Parent Cell Line:	E14 (ES Cell)
Strain of Origin:	129P2/OlaHsd

Allele Type:    Targeted (RMCE-ready) Mutation:    Insertion   Mutation details: Recombination-mediated cassette exchange (RMCE) was used to replace exons 76 through 89 with an frt-flanked cassette containing a cDNA for exons 76 through 89 and a floxed neo gene. (J:144146)

View phenotypes and curated references for all genotypes (concatenated display).

In Mice Carrying this Mutation:

6 assay results

Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:	Mouse Strains: 1 strain available      Cell Lines: 0 lines available
Carrying any Lrp1 Mutation:	211 strains or lines available

Original:	J:144146 Roebroek AJ, et al., Mutant Lrp1 knock-in mice generated by recombinase-mediated cassette exchange reveal differential importance of the NPXY motifs in the intracellular domain of LRP1 for normal fetal development. Mol Cell Biol. 2006 Jan;26(2):605-16
All:	1 reference(s)