Ifngtm2(CD4*)Lky
Targeted Allele Detail
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Symbol: |
Ifngtm2(CD4*)Lky |
Name: |
interferon gamma; targeted mutation 2, Richard M Locksley |
MGI ID: |
MGI:3829361 |
Synonyms: |
DTAG |
Gene: |
Ifng Location: Chr10:118276951-118281797 bp, + strand Genetic Position: Chr10, 66.75 cM
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Alliance: |
Ifngtm2(CD4*)Lky page
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Germline Transmission: |
Earliest citation of germline transmission:
J:142395
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Parent Cell Line: |
Not Specified (ES Cell)
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Strain of Origin: |
Not Specified
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Allele Type: |
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Targeted (Humanized sequence, Inserted expressed sequence, Reporter) |
Mutation: |
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Insertion
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Ifngtm2(CD4*)Lky expresses
2 genes
Knock-in expresses:
Organism |
Expressed Gene |
Homolog in Mouse |
Note |
human |
CD4 (920) |
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mouse |
Ifng (MGI:107656) |
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Mutation details: The following was inserted at the translation start site: a destabilized enhanced cyan fluorescent protein (d2ECFP), a viral self-cleaning 2A sequence, 4 introns and exons of the Ifng gene, a viral IRES, a mutated non-signaling human CD4 cDNA and an endogenous polyadenylation site. Expression at this locus produces ECFP, the Ifng transcript and a non-signaling human CD4.
(J:142395)
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Mouse strains and cell lines
available from the International Mouse Strain Resource
(IMSR) |
Carrying this Mutation: |
Mouse Strains: 0 strains available
Cell Lines: 0 lines available
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Carrying any Ifng Mutation: |
47 strains or lines available
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DTAG = Dual Targeted At IFN-Gamma locus
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Original: |
J:142395 Kang SJ, et al., Regulation of hierarchical clustering and activation of innate immune cells by dendritic cells. Immunity. 2008 Nov;29(5):819-33 |
All: |
1 reference(s) |
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