Summary | Mutation origin | Mutation description | Phenotypes | Find Mice (IMSR) | References

Symbol:	Cacna1ctm1Msmg
Name:	calcium channel, voltage-dependent, L type, alpha 1C subunit; targeted mutation 1, Sven Moosmang
MGI ID:	MGI:3829031
Synonyms:	S1928A KI
Gene:	Cacna1c  Location: Chr6:118564201-119173851 bp, - strand  Genetic Position: Chr6, 55.86 cM
Alliance:	Cacna1ctm1Msmg page

Germline Transmission:	Earliest citation of germline transmission: J:143613
Parent Cell Line:	R1 (ES Cell)
Strain of Origin:	(129X1/SvJ x 129S1/Sv)F1-Kitl+

Allele Type:    Targeted (Inserted expressed sequence) Mutation:    Insertion   Mutation details: An exon 45 mutation causing a serine to alanine change at codon 1928 (S1928A) was inserted together witha floxed neomycin/tk selection cassette. The selection cassette was then excised by transient cre expression. (J:143613)

View phenotypes and curated references for all genotypes (concatenated display).

Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:	Mouse Strains: 1 strain available      Cell Lines: 0 lines available
Carrying any Cacna1c Mutation:	141 strains or lines available

Original:	J:143613 Lemke T, et al., Unchanged beta-adrenergic stimulation of cardiac L-type calcium channels in Ca v 1.2 phosphorylation site S1928A mutant mice. J Biol Chem. 2008 Dec 12;283(50):34738-44
All:	5 reference(s)